When the inflammation from a severe infection or injury causes dysfunction in two or more organ systems, this is called multiple organ system failure. Multiple organ dysfunction syndrome can affect any or all of six organ systems: respiratory (lungs), cardiovascular (heart), renal (kidneys), hepatic (liver), neurologic (brain) and hematologic (blood).
Respiratory: Respiratory failure occurs when the lungs are damaged as a result of injury, infection, or surgical complications and the body either doesn’t get enough oxygen or builds up too much carbon dioxide.
Cardiovascular: Heart failure can occur when the heart muscle is too weak or stiff to pump blood properly. Heart failure can lead to both kidney and liver damage, as the blood flowing from the heart to the kidneys may decrease, and the liver may experience pressure from fluid buildup.
Renal: Acute renal failure happens when the kidneys are not able to filter waste from the blood. When the kidneys lose this ability, dangerous levels of waste can accumulate, and the blood’s chemistry may become unbalanced.
Hepatic: Liver failure occurs when large parts of the liver become damaged beyond repair and the liver can no longer function.
Neurologic: Brain injuries can be caused by physical trauma, or by non-traumatic medical factors, such as meningitis, tumors, aneurysms, or strokes. Because the brain controls all bodily functions, injury to this organ has wide-reaching effects.
Hematologic: Bleeding in the gastrointestinal tract or breaks in the skin are common when someone is experiencing multiple organ failure. This can be very difficult to control or stop.
Currently, there is no drug or therapy that can reverse organ failure; however, organ function can recover to some degree. Mechanical ventilation and dialysis are two treatments that can support specific organ functions.